For the measurement of tumor state outwardly using tissue samples for the study, researchers have revealed a technique based on magnetic resonance imaging of entire body segments. This technique is using for the measurement of proton nuclear resonance dispersion profiles in low magnetic fields, which exposes the water exchange rate of the tumor cells. Thus, tumor growth can be observed rapidly and noninvasively.
Whenever we used high-field MRI using clinically, It can produce images of tumors with excellent and superior spatial resolution. The images are obtained by a fixed magnetic field and expose relevant data on the tumor morphology.
The researcher practiced a field-cycling nuclear magnetic resonance setup to measure the nuclear relaxation speeds at low magnetic fields and found a sharp relationship between the water dynamics and those tumor types.NMR fast field cycling techniques measure the relaxation time of protons, the dispersion profiles, after a sequence of magnetic cycles in a magnetic field. Depending on the strength of the magnetic field, different proton conditions can be probed.
In this study, the team used an adapted NMR instrument, which switches between different field strengths, for data acquisition on tumors in animal models.
Later monitoring the kinetics of the curves, the researchers classified three underlying forms:
1. Quiet water exchange flow
2. fast replacement
3. A between exchange rate with contributions from both intra and extracellular sections.
An active exchange shows a high metabolic flow and thus a high action of the tumor cell. This enhanced metabolic action is essential for aggressive and very extremely metastatic tumor cells. The tumor cells reduce their high metabolic pressure by an enhanced water exchange with the surface of the cell. This parameter is now directly obtainable with this method, as the experts have proved.
The specialists describe the process as "a possibility for new diagnostic opportunities in oncology."
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